Bioconjugation technology has caused the birth of billion-dollar industries serving research, diagnostics, and therapeutic markets. A significant portion of all biological assays, including clinical testing, is now done using unique bioconjugates that have the ability to interact with particular analytes in solutions, cells, or tissues. Crosslinking and modifying agents can be applied to alter the native state and function of peptides and proteins. Through careful modification or conjugation strategies, the structure and function of peptides and proteins can be investigated, active site conformation discovered, or receptor-ligand interactions revealed.
Modification with peptides with certain molecules such as oligonucleotides, fluorescent dyes, chromogenic enzyme substrates, drugs, toxins or carrier proteins is supposed to be an effective improvement strategy. Taking the peptide-drug conjugates for example, such a transformation system was thought to be able to bypass the identification of macrophage crossing biological obstacle and accrete the entrance of the target cell. Organometal-peptide bioconjugates have a variety of applications in biomedical studies, such as anti-proliferative and anti-bacterial activity, as well as to aid the elucidation of the mode of action of the conjugated metal complexes. Besides, the incorporation of metals may bring about a new and unprecedented activity or selectivity, or it may offer additional, metal-specific means of detection, such as Atomic Absorption Spectroscopy (AAS).
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