BOC Sciences offers custom synthesis and manufacturing services for biotechnology, pharmaceutical, life science, chemical research, and related industries. A series of chemical reactions are carried out for the purpose of obtaining one or more organic molecules. As an integral part of drug discovery or other chemical industries, chemical synthesis plays an important role in the screening of numerous potential active ingredients. Leveraging this expertise, BOC Sciences provides comprehensive capabilities including API synthesis, chiral synthesis, bioconjugation, stable isotope labeling, multi-type reaction development, and process R&D, supporting synthesis from milligram to kilogram scale with full analytical documentation and traceability to efficiently meet diverse research and development needs.
Active pharmaceutical ingredient (API) is a part of a drug product that produces primary therapeutic effects. Some kinds of dosage forms, such as compound preparation, possess two or more active ingredients that is designed to treat different symptoms or integrate synthetical effects. BOC Sciences provides comprehensive API synthesis services, including custom design, process development, and scalable production, ensuring high purity and consistent quality to meet diverse research and commercial needs. Our expertise supports efficient and cost-effective API supply for pharmaceutical development projects.
Chiral synthesis, also known as enantioselective synthesis, has a great importance in the screening of APIs and development of bio/pharmaceutical products. BOC Sciences offers professional chiral synthesis services, including the design and optimization of enantioselective routes, scalable production of optically pure compounds, and analytical support to ensure high enantiomeric purity. Our capabilities help accelerate drug discovery and development by providing reliable and efficient solutions for complex chiral molecules.
Bioconjugation represents the technique of giving a target substance with certain desired properties through the site-specific reaction between the biomolecules and exogenous moieties (usually one or several other molecules). Through such covalent linkage approach, a broad range of innovative drug substances or end products are designed to improve the accuracy of disease diagnosis, pharmacokinetic properties, treatment efficacy and many other aspects. BOC Sciences offers tailored bioconjugation services, delivering precise and customizable molecule-linking solutions.
The practice of stable isotope labeling is a widely utilized method across the scientific disciplines, spanning chemistry, biology, and environmental science, among others, in order to effectively monitor the migration of atoms or molecules within a given system. The process itself involves the substitution of one or more atoms present within a molecule with a stable isotope of the identical element, wherein the likes of carbon-12 is supplanted by carbon-13, for example. BOC Sciences specializes in the custom synthesis of small molecules, including 13C-, 15N-, and 2H-labeled compounds and other isotopic products for drug development.
Chemical reactions are the processes by which chemicals interact to form new chemicals with different compositions. Simply stated, a chemical reaction is the process where reactants are transformed into products. How chemicals react is dictated by the chemical properties of the element or compound-the ways in which a compound or element undergoes changes in composition. BOC Sciences provides expertise in reaction development, optimization, and scale-up to support efficient chemical synthesis for research and industrial applications.
An effective process R&D is an essential part of your drug development while it plays important role in controlling costs, ensuring product's quality and meeting the requirements of regulations. More importantly, package solutions are available to address any problems and potential risks that significantly impact the quality of your products. BOC Sciences offers comprehensive process R&D services, including route optimization, scale-up, and troubleshooting, providing reliable and efficient support to enhance productivity and streamline pharmaceutical development.
Our synthesis specialists are ready to provide a rapid feasibility assessment and customized quote.
At BOC Sciences, we offer comprehensive custom synthesis services to support a wide range of research and development projects. Our expertise spans diverse molecular categories, providing tailored solutions to meet your specific scientific needs. Our service offerings include the following:
Outline your synthesis needs, and we'll develop a scalable, cost-effective route tailored to your project timeline and quality standards.
At BOC Sciences, we offer comprehensive custom synthesis services covering a wide range of commonly used chemical reaction types to support diverse research and process development needs. The table below highlights reaction types frequently employed in organic synthesis, chiral synthesis, and functional modifications, enabling applications from small molecule construction to complex molecular assembly.
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Our custom synthesis service platform is equipped with a comprehensive array of advanced instrumentation designed to support the efficient production, purification, and characterization of a wide range of small molecules, peptides, lipids, and oligonucleotides. The platform integrates state-of-the-art synthetic, analytical, and purification technologies, ensuring high-quality compound production with precise structural verification.
Our custom synthesis projects follow a clear and transparent process to ensure efficiency, quality, and customer satisfaction:
Clients outline their requirements, including target molecules, specifications, and scale.
Our chemists assess synthetic routes, potential challenges, and overall technical viability.
We provide estimated costs together with recommended specifications to optimize resources.
A formal quotation and agreement are established to confirm project scope, timelines, and deliverables.
Laboratory synthesis begins, with progress updates provided every two weeks to keep clients fully informed.
Comprehensive analytical data are generated, including HPLC, GC-MS, and NMR, to confirm structure and purity.
Clients review results and approve before project finalization.
Compounds are securely packaged and delivered promptly, accompanied by all supporting documentation.
This structured workflow ensures reliable outcomes, transparent communication, and full traceability from inquiry to delivery.
The deliverables include comprehensive synthesis records (original lab notebooks, TLC monitoring, etc.) and a full suite of analytical data, such as HPLC, MS, and NMR, providing complete information to support product evaluation, quality assessment, and process understanding.
Our experienced chemists design and optimize synthetic routes, efficiently addressing challenging molecular targets.
We integrate process research with iterative optimization, improving yield and purity across multi-step reactions efficiently.
We support synthesis from milligram to kilogram scale, ensuring consistent quality and reproducibility across batch sizes.
State-of-the-art instrumentation, including NMR and LC-MS, allows comprehensive characterization for complex molecules.
Dedicated project managers coordinate timelines and resources, enabling simultaneous handling of multiple custom synthesis projects.
Streamlined workflows and scalable processes reduce turnaround time by 15–25%, delivering cost-effective solutions without compromising quality.
We offer end-to-end custom synthesis services for molecules ranging from simple organics to complex biomolecules. Our processes ensure precision, scalability, and consistent quality for research and production.
Provides diverse small molecules, fragments, and derivatives for drug discovery, supporting structure optimization and high-throughput screening.
Supplies API precursors and key intermediates to support process development and pilot-scale production.
Synthesizes isotopically labeled, fluorescent-labeled, or other specially functionalized molecules for mechanistic studies and analytical applications.
Delivers heterocycles, small-molecule natural product derivatives, and chiral molecules that are difficult to obtain through conventional sources.
Client: A biotech company developing lipid-based therapeutics
Challenge: The client required synthesis of modified lipid conjugates with diverse head groups and tail modifications to enhance molecular functionality. Traditional synthesis methods struggled with regioselectivity, chain-length diversity, and scalability.
Solution: BOC Sciences implemented an advanced lipid synthesis workflow using automated coupling strategies and orthogonal protecting group chemistry. Customized reagents and optimized solvent systems enabled precise incorporation of diverse functional groups and tailored chain lengths. Analytical checkpoints were applied throughout the workflow to monitor structural integrity and minimize side-product formation.
Outcome: The client obtained a panel of structurally diverse, high-quality lipid conjugates for detailed functional assessment. This approach facilitated rapid iteration, supporting efficient exploration of lipid structure–activity relationships and providing a reliable platform for lipid-based therapeutic development.
Client: A pharmaceutical R&D company developing kinase inhibitors
Challenge: The client required rapid synthesis and diversification of a series of small-molecule kinase inhibitors with varied substituents to explore structure-activity relationships. Conventional synthesis methods were time-consuming and limited in flexibility for scaffold modification.
Solution: BOC Sciences implemented a modular synthetic strategy using parallel chemistry techniques and automated reaction optimization. Adaptable protecting group strategies and regioselective functionalization allowed the efficient generation of multiple analogs. In-line analytical monitoring ensured precise control of reaction pathways and minimized undesired by-products.
Outcome: The client obtained a diverse library of kinase inhibitor analogs suitable for rapid evaluation. Our approach accelerated iterative compound design, enabling efficient exploration of structure-activity relationships and supporting informed lead optimization decisions.
Client: A drug discovery company exploring heterocyclic scaffolds
Challenge: The client required novel heterocyclic building blocks with diverse substitution patterns to support medicinal chemistry campaigns, where conventional sourcing options were limited.
Solution: BOC Sciences developed a flexible custom synthesis workflow combining multi-step heterocycle assembly with selective functionalization. Reaction conditions were optimized for various scaffold types, and intermediates were characterized using advanced spectroscopic and chromatographic techniques. Parallel synthesis allowed multiple derivatives to be produced with structural precision.
Outcome: The client obtained a curated library of heterocyclic intermediates, accelerating scaffold exploration and analog design. The tailored workflow improved synthetic efficiency and provided a dependable supply of high-quality intermediates for medicinal chemistry programs.
Designing a synthetic route requires a comprehensive assessment of the target molecule’s structural complexity, functional group distribution, and potential reaction pathways. Common strategies include retrosynthetic analysis to deconstruct the target, selection of efficient and controllable key intermediates, and optimization of steps based on literature or database experience. For complex molecules, computational chemistry tools can help evaluate reaction feasibility and potential side reactions, significantly improving the likelihood of success. BOC Sciences can provide clients with tailored synthetic route evaluation and optimization, ensuring scientifically robust design.
The feasibility of a custom synthesis largely depends on the chemical stability and reactivity of the target molecule, as well as the availability of starting materials and intermediates. Molecules with high structural complexity, stereochemical requirements, or sensitive functional groups typically present higher challenges. Additionally, the choice of solvents, catalysts, and reaction conditions directly affects reaction efficiency and reproducibility. Experienced synthesis teams can leverage accumulated chemical knowledge and experimental expertise to assess the feasibility and optimization potential of different approaches for clients.
Strategies to minimize by-products include selecting the most suitable reaction pathway, controlling reaction temperature and time, employing protecting group strategies for sensitive functional groups, and using highly selective catalytic systems. In multi-step synthesis, monitoring and purifying intermediates is also critical. These measures can significantly improve overall yield and product quality, providing reliable material for subsequent applications.
Scaling up from milligram to gram quantities requires consideration of heat management, mixing uniformity, and changes in reaction kinetics. Conditions that are stable at a small scale may lead to side reactions or lower yield when scaled up. Therefore, stepwise scale-up and staged optimization are necessary. BOC Sciences can offer scientifically informed adjustments during scale-up to ensure a smooth transition to larger quantities.
Ensuring product purity and consistency relies on precise control of reaction conditions, the use of highly selective reagents, and rigorous monitoring and purification of intermediates. In multi-step syntheses, quality control at each stage is critical to guarantee the stability of the final product. BOC Sciences leverages standardized procedures and accumulated expertise to provide clients with high-quality, reproducible custom products.
BOC Sciences' custom synthesis service demonstrates exceptional technical expertise. Their team translated our complex molecule design into tangible results with impressive accuracy. The thorough approach to reaction optimization and stepwise monitoring has enhanced our project planning efficiency.
— Dr. M., Senior Research Scientist, Pharmaceutical R&D Division
Working with BOC Sciences for custom synthesis has been highly productive. Their collaborative communication and willingness to adapt protocols to our specifications streamlined our workflow. The technical insights provided during intermediate stages helped us refine our project strategy effectively.
— Dr. S., Principal Scientist, Specialty Chemical Company
The custom synthesis solutions from BOC Sciences consistently meet challenging structural requirements. Their innovative approaches to reaction design and troubleshooting allowed us to explore novel chemical scaffolds with confidence. This capability significantly accelerated our exploratory research.
— Dr. K., Head of R&D, Biotech Start-up
BOC Sciences delivers highly reproducible synthetic outcomes, even for complex targets. Their systematic approach to reaction monitoring and intermediate validation ensures reliable results, which has strengthened our internal project pipelines and decision-making.
— Dr. T., Lead Chemist, Agrochemical Research Group
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