Heterocycles Synthesis

BOC Sciences can partner with multiple R&D organizations to provide rapid customization and synthesis of small batch, multi-species compounds, with particular expertise in the areas of carbohydrates, steroids, lipids, polycyclic aromatic hydrocarbons (PAHs), oligonucleotides, and more.

Fig 1. Synthesis of Saturated N-Heterocycles. (Vo et al., 2014)

What are Heterocyclic Compounds?

Heterocyclic compounds are probably the most widely used and diverse family of molecular fragments in organic synthesis. Many heterocyclic skeletons have been identified as preferred structures in medicinal chemistry and are widely present in a wide range of pharmacologically active synthetic and natural compounds. The atoms that make up the ring contain at least one heteroatom in addition to the carbon atom. The most common heteroatoms are nitrogen, sulfur, and oxygen atoms. They can be categorized into two main groups: aliphatic heterocycles and aromatic heterocycles.

Services for Heterocyclic Compound Synthesis

• Design of heterocyclic compound synthesis

Before proceeding with the synthesis of heterocyclic compounds, the heterocyclic compounds need to be designed. Most chemical reaction design programs begin with the synthesis of building blocks. By combining synthetic blocks with different compounds, a comprehensive heterocyclic compound synthesis can be provided. In addition, several factors need to be considered depending on the client's needs, such as, the structure of the target molecule, available starting materials and intermediates, choice of reaction type, protecting groups and functional group conversions.

• Heterocyclic compound synthesis

Heterocyclic compound synthesis can be carried out on the basis of different reactions. These reactions can be cyclization, condensation, cycloaddition, azotization, and oxidation. The exact synthesis method will vary depending on the structure of the target compound and the functional groups required.

• We offer the types of heterocyclic compounds synthesized
• Imidazoles (containing a five-membered heterocyclic ring with a heteroatom of three nitrogen atoms)

Customized products may include Imidazole, Imidazoline, 1-Methyl-4-acetylimidazole, 1,2-Dimethylimidazole, 2-Ethoxyimidazole, 5-Fluorimidazole, and others.

• Thiophenes (containing a five-membered heterocyclic ring with the heteroatom being a sulfur atom and three hydrogen atoms)

We offer customized products including Thiophene, 2,5-Dimethylthiophene, 3-Ethylthiophene, 2-Chlorothiophene, 3-Nitrothiophene, Thiophene dimer, Thiophene polymer, and so on.

• Pyrroles (containing a five-membered heterocycle, the heteroatoms being a nitrogen atom and three hydrogen atoms)

We offer customized products including Pyrrole, 2-Methylpyrrole, 3-Vinylpyrrole, 2,5-Dimethylpyrrole, 3-Aminopyrrole, Pyrrole-vinyl polymer, Pyrrole-imidazole conjugate, etc.

• Piperidines (containing a six-membered heterocyclic ring where the heteroatoms are one carbon atom and five nitrogen atoms)

We offer customized products including Piperidine, 1-Methylpiperidine, 4-Methylpiperidine, 1-Ethylpiperidine, 1-Cyclopentylpiperidine, 4-Aminopiperidine, Piperidine sulfonic acid, Piperidinone, etc.

• Thiophenes (containing a six-membered heterocyclic ring, the heteroatoms being a sulfur atom and four hydrogen atoms)

We offer customized products including Thiophene, 2,5-Dimethylthiophene, 3-Ethylthiophene, 2-Chlorothiophene, 3-Nitrothiophene, Thiophene dimer, Thiophene polymer, and more.

• Pyrroles (containing a six-membered heterocycle, the heteroatoms being a nitrogen atom and four hydrogen atoms)

We offer customized products including Pyrrole, 2-Methylpyrrole, 3-Vinylpyrrole, 2,5-Dimethylpyrrole, 3-Aminopyrrole, Pyrrole-vinyl polymer, Pyrrole-imidazole conjugate, etc.

• Optimization of synthetic routes

Optimization of synthetic routes of heterocyclic compounds can be carried out by optimization of conditions, optimization of reactants, synthesis of intermediates, sequence of synthetic steps, selection and optimization of catalysts, and optimization of solvents. Under product scale-up and large-scale production, adjustments need to be made according to specific needs and systematic experimental validation needs to be performed to ensure the feasibility and validity of the designed route.

BOC Sciences provides quality control systems to ensure that the entire synthesis of heterocyclic compounds is reliable and can be reproduced and applied under different conditions. If you are interested in our services, feel free to contact us.