Amination
Amination is the reaction process of introducing amine groups (-NH2) into organic molecules to form amines. Amines as a very potent drug functional group exist in most drug structures. For example, cyclized amines are considered to be the pharmacophores of penicillin drugs. Modern medicinal chemistry research and design have positioned amine structures as one of the most important pharmacophores. Amino groups are not only the key active groups of various drug substances, but also the important intermediates and ligands in organic synthesis chemistry. In general, the amino groups can be divided into two types with the one is reductive amination and the other one is aminolysis.
Below is a list of our Amination Services:
- Amination of 2-Chloroanthraquinone using ammonia
- Amination of naphthalene via the bucherer reaction
- Amination of 2-furaldehyde using ammonia
- Amination via the chichibabin reaction
Our Advantages
High temperature and high pressure reactors
Ammonia is used for catalytic amination in gas phase, and it must be carried out under high temperature and high pressure. Our new high pressure equipment accommodates most reagents and is fabricated from stainless steel.
Amine/ammonia delivery system
In the case of gaseous amines, the transfer system must be considered. And in some cases, the carbonyl compound is added to the amine in the pressurized system to affect the selectivity. A high pressure feed pump is used to add the carbonyl compound at a controlled rate.
Amine/ammonia scrubbing system
After the completion of the amination, the work has not yet ended. Excess amine/ammonia must be separated from the crude mixture. In large systems, these materials can be reused in subsequent batches. BOC Sciences manages excess by using absorbents and neutralizers at all scales.
Process control system
All projects are individually evaluated according to their process control requirements. Typically, customized control systems are implemented to maintain optimal reaction conditions. This ability ensures a safe amination process.
Purification of the crude product
Distillation is a commonly used technique for the purification of amination crude products. Common impurities often have a large enough difference in boiling point to make distillation a good choice.
Process waste
Detailed waste characterization and analysis can ensure that we safely handle the amination process waste and also allow the waste to be separated by special treatment.
BOC Sciences has considerable experience in various amination pathways. We have different types of reactors that have the ability to handle a variety of amination reactions. With many years of experience in providing amination services, we are your best choice.
References
- Müller, T. E., & Beller, M. (1998). Metal-initiated amination of alkenes and alkynes. Chemical reviews, 98(2), 675-704.
- Surry, D. S., & Buchwald, S. L. (2011). Dialkylbiaryl phosphines in Pd-catalyzed amination: a user’s guide. Chemical Science, 2(1), 27-50.