Formulation Development
BOC Sciences provides powerful formulation development services to support the development of many chemical substances. Our experts are fully aware of the importance of developing stable and compliant formulations to help customers find the right API and the best dosage forms for pharmaceuticals. Our R & D team has extensive experience in formulation research and analysis, as well as in collaborative practice with global customers for formulation development and analytical support. Our goal is to help the testing of molecules speed through the early stages and prepare our customers for commercial success faster.
We have experience formulating a variety of dosage forms:
Below is a list of our formulation development services:
Early stage formulation development and proof can help de-risk the drug development process and avoid costly late-stage failures are needed urgently. Early stage formulation development strategies focused on the development of formulations that can be manufactured using simple and low-cost processes, and also focused on the development of formulations with a high probability of clinical success.
Seamlessly transfer of the knowledge which is gained during late stage of formulation development to commercial-scale pharmaceutical manufacturing can be ensured by our experienced drug formulation development expertise. The final formulation development aims to optimize the pharmacokinetic properties of drugs with good ADME.
Due to the serious shortage of hand sanitizer and other disinfection products caused by the global COVID-19 pandemic, BOC Sciences currently provides you with the formulation service of hand sanitizer and other products, and provides you with the opportunity to own your own brand hand sanitizer and other products. If you are interested in our services, please feel free to contact us for more details.
- Hand Hygienic Gel
- Hygienic Antibacterial Sanitizer
- Surface Cleaner Spray
We cover every step of the initial route that detects intermediate products and API procurement. Small molecules have considerable advantages over large molecules. They can produce strong therapeutic effects at low dosage, usually below 10 nanogrames and up to micrograms. Smaller quantities of APIs, coupled with the maturity of chemical manufacturing technologies, usually translate into lower commodity costs than macromolecular therapies. Small molecule analysis technology is highly refined to ensure quality, efficacy and reproducibility.
The route of administration is closely related to the therapeutic effect of clinical drugs. Different routes of administration can affect the drug's absorption rate, bioavailability, onset time and maintenance time of drug effect, and even change the drug's action properties. The route of administration includes oral administration, intravenous injection, intramuscular injection, intradermal injection, epidermal injection, inhalation, intraperitoneal administration, local administration and the like. With the development of pharmaceutical dosage forms, it is of great significance to choose the appropriate pharmaceutical dosage form and route of administration. Our scientific team has experience with many routes of administration and can help clients understand the intended route of administration.
Oral solid preparations (tablets and capsules) are some of the most popular and convenient methods of drug delivery. They can be produced in a non-aseptic environment. After more than 100 years of development, their processes, equipment and technologies have been well defined and understood. Such facilities typically include warehouses with receiving and shipping areas, clean processing rooms, clean support processing zones for rapid turnover, without unacceptable risks of product exposure (eg. dust and cross-contamination).
Soft gel technology is becoming an increasingly popular dosage form in the market of prescription drug (Rx) and over-the-counter drug (OTC). From better stability to easier swallowing, soft gel formulations offer many benefits.
Various dosage forms, including large and small parenteral tracts, liquid and freeze-dried vials, prefilled syringes and cartridges. For example, formulation and process development; development and optimization of freeze-drying cycles; proper treatment of sensitive and valuable drugs; clinical trial services, including prefilled syringes and automatic syringe components.
Acting as a well-established tool, LCM has been widely use to maximize sales, greater profitability, intensify competitive edge and retain market share. LCM planning is no doubt continue to be the most optimal and popular strategy for addressing the declining R&D productivity and stricter reimbursement demands, especially in the increasingly competitive market.
Equipped with the latest analytical platforms and top-notch techniques, our product development teams can work with our customers to optimize the technology, formulation components, manufacture procedure, dosage forms and advance the product concepts to clinical trials and commercial manufacture. To meet your solubilization improvement requirements, we can provide a broad suite of technologies and formulation approaches such as micronization, spray dried amorphous solid dispersion and other techniques.
Formulation development is a key step in determining the success of drug development. BOC Sciences has complete facilities and years of formulation development experience to help our customers at all stages of drug development, ensuring that the products can reach the market in the shortest possible time. For more information about BOC Sciences and formulation development related services, please contact us.
References
- Shafiq-un-Nabi, S., Shakeel, F., Talegaonkar, S., Ali, J., Baboota, S., Ahuja, A., ... & Ali, M. (2007). Formulation development and optimization using nanoemulsion technique: a technical note. AAPS pharmscitech, 8(2), E12-E17.
- Hamilton, R. B., & Newman, J. P. (2018). The response modulation hypothesis: Formulation, development, and implications for psychopathy.