PEGylated lipids are PEG derivatives containing lipid molecules that can be used for bioconjugation and lipid nanoparticle (LNP) drug delivery to improve the circulation time of liposome-encapsulated drugs. Lipid molecules are characterized by low toxicity and ease of preparation, and can be used as carriers for not only water-soluble but also lipid-soluble drugs. BOC Sciences offers the synthesis of PEGylated lipids and provides services for modification of functionalized PEG ends, including amines, carboxylic acids, azides, aldehydes, thiols and hydroxyls.
Fig. 1. Structures of the LP and PEGylated lipid. (Ho et al., 2018)
Polyethylene glycol (PEG) is an inert, non-carcinogenic polymer and is currently one of the polymers of choice for modifying the surface of bioactive molecules and nanoparticles. PEG is inexpensive, mass-producible, has an easily controlled molecular weight, and has good physicochemical properties, and PEG-derived lipids can reduce the leakage rate of liposomes, decrease aggregation and fusion, and prolong the expiration date. Moreover, the good stability of PEGylated liposomes allows them to be used in other drug delivery systems, such as encapsulating contrast agents in PEG liposomes for diagnostic imaging of organs such as the kidneys, or making sprays for the treatment of lung diseases such as tuberculosis.
BOC Sciences offers a full range of integrated PEGylated lipids synthesis services, including the design of PEGylated lipids, modification of PEG terminal groups, and custom synthesis of PEGylated lipids, to help customers develop projects in the pharmaceutical field.
The structure and length of the PEG chain as well as the functional end groups are factors that affect its function. Also, parameters such as PEG size and surface charge affect immunogenicity. For example, polyethylene glycolized carriers containing negatively charged phospholipids are more capable of stimulating the immune system through complement activation than uncharged vesicles.
In addition, as with the PEG fraction, the structure and length of the hydrophobic chains of lipids can determine not only the degree of immunogenicity but also its effectiveness. Whereas, polyethylene glycolated lipid nanoparticles produced using a specific lipid anchoring group (e.g., cholesterol as an anchoring group) have longer lasting permeability and higher systemic bioavailability in circulation. Attention also needs to be paid to the role of lipid bonding, which is an important parameter in lipid design and performance.
All these factors need to be considered during the design process of PEGylated lipids and the PEGylated lipids products need to be customized for specific structure, length and function.
Based on the various applications of PEGylated lipids, PEG terminal groups can be modified to impart specific functional and chemical properties to the PEGylated lipids molecule. We offer PEG terminal modifications including amino, hydroxyl, carboxyl, sulfur, alkynyl, ether and azide groups. These chemical reactions can be carried out in our specialized organic synthesis chemistry laboratory, guaranteeing you high-quality products.
Upon completion of the design of the target PEGylated lipids, BOC Sciences can provide custom synthesis of PEGylated lipids. The lipids need to be dissolved in an organic solvent first to form a clear solution. Then, the target polyethylene glycol is gradually added to the lipid solution and stirred until a homogeneous mixture is formed. The excess solvent is then removed and the lipid-polyethylene glycol mixture is resuspended with water to form a mixture of PEGylated lipids.
BOC Sciences provides a comprehensive PEGylated lipid synthesis platform designed to support advanced research and pharmaceutical development. Our services combine expertise in lipid chemistry, polymer modification, and analytical verification, ensuring products meet the highest standards for quality, stability, and functionality.
1. Tailored Lipid Design
Each PEGylated lipid can be customized in terms of PEG chain length, functional end groups, and hydrophobic tail composition. This flexibility enables the creation of nanoparticles with optimized circulation time, controlled release profiles, and enhanced bioavailability for various research applications.
2. Functional PEG Modifications
Our team can introduce a wide range of functional groups, including amino, hydroxyl, carboxyl, sulfur, alkynyl, ether, and azide groups. These modifications enhance chemical versatility, improve stability, and enable conjugation with targeting moieties, drugs, or imaging agents.
3. High Purity and Reproducibility
Through rigorous purification and quality control, PEGylated lipids produced by BOC Sciences achieve high chemical purity, uniform molecular weight distribution, and consistent performance across batches. This reliability is critical for reproducible results in experimental and preclinical studies.
4. Advanced Analytical Verification
All synthesized lipids are verified using state-of-the-art analytical techniques, including NMR, mass spectrometry, and chromatographic profiling. This ensures structural integrity, functional fidelity, and compatibility with downstream applications such as liposome formulation or nanoparticle assembly.
5. Scalable Production and Timely Delivery
BOC Sciences supports both small-scale experimental needs and larger-scale synthesis projects. Efficient workflows and scalable protocols allow timely delivery without compromising product quality, enabling researchers to meet project deadlines effectively.
6. Integrated Research Support
Beyond synthesis, BOC Sciences provides guidance on lipid selection, formulation strategies, and storage conditions. Our integrated support helps clients maximize the functionality of PEGylated lipids in drug delivery, diagnostics, and biomedical research.
We offer lipids synthesis services with expertise in pegylated-lipids and triglycerides, delivering tailored properties, high purity, and consistent quality to support diverse research needs.
Submit your inquiry to request a custom solution.
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