BOC Sciences provides end-to-end medicinal chemistry services that comprehensively support the entire drug development process, from hit identification and lead optimization to preclinical candidate selection and process development. Leveraging our expertise in custom synthesis, structure-activity relationship (SAR) studies, route scouting, impurity profiling, and scale-up production, we deliver tailored chemical solutions for small molecules, peptides, nucleotides, lipids, and other drug-like entities. Our integrated approach ensures high efficiency, technical consistency, and flexible project execution to accelerate the advancement of your pharmaceutical pipeline.
Drug development is a complex and iterative process often challenged by issues such as poor hit compound quality, low bioavailability, metabolic instability, synthetic route inefficiency, and difficulty in achieving optimal pharmacological profiles. Researchers may also encounter bottlenecks in impurity identification, stereochemical resolution, and process scale-up, all of which can delay project timelines and increase development costs. BOC Sciences offers a fully integrated suite of medicinal chemistry services designed to address these pain points effectively. Our capabilities span from hit identification and lead optimization to complex scaffold modification, SAR-guided design, chiral compound synthesis, impurity control, and process route development. With extensive expertise and flexible project support, our team delivers tailored, science-driven solutions that accelerate compound optimization, improve synthetic feasibility, and enhance the overall success rate of pharmaceutical R&D programs. BOC Sciences stands as a reliable and strategic partner throughout every critical stage of drug discovery and development.
We offer extensive synthetic capabilities covering small molecules, lipids, peptides, oligonucleotides, chiral compounds, and bioconjugates, enabling support across all stages of drug discovery.
Our chemists possess deep expertise in a wide range of reaction types, including asymmetric synthesis, heterocycle construction, and late-stage functionalization, ensuring high-quality compound delivery.
We specialize in designing and optimizing novel synthetic routes tailored to your specific targets, balancing yield, cost, safety, and scalability considerations.
Equipped with advanced instrumentation (e.g., NMR, LC-MS, HPLC), we ensure accurate structural confirmation, purity analysis, and batch reproducibility to support confident decision-making.
From milligram to multigram scales, our infrastructure supports flexible production volumes to meet diverse research demands, including feasibility studies and lead candidate preparation.
Our project managers maintain seamless communication with clients, providing regular updates, technical consultation, and adaptive timelines to ensure on-time and on-spec compound delivery.
BOC Sciences provides a full suite of medicinal chemistry services to empower pharmaceutical discovery and development. With advanced synthetic capabilities, modular service design, and deep technical expertise, we deliver reliable, scalable, and customizable chemistry solutions tailored to meet the demands of modern drug innovation.
We offer end-to-end custom synthesis services covering simple scaffolds to structurally complex molecules. Our team specializes in small molecule synthesis, lead compound modification, analog library construction, and impurity generation, supporting early discovery, hit validation, and SAR exploration.
We provide a flexible synthesis of active pharmaceutical ingredients (APIs), key starting materials, and intermediates at various scales. Our chemists specialize in developing novel synthetic routes or optimizing existing pathways to meet specific project needs in terms of purity, yield, and scalability.
We deliver chiral chemistry services that encompass asymmetric synthesis and chiral pool approaches as well as enantiomer separation through chiral chromatography. We provide essential chiral materials like building blocks and ligands which enable researchers to achieve stereoselective synthesis with high enantiopurity and consistent results.
The company BOC Sciences extends specialized synthetic capabilities beyond their traditional methods to include carbohydrate synthesis as well as lipid synthesis with variations like PEGylated, fluorescent, and biotinylated lipids in addition to glycolipids, heterocycles, and labeled compounds. Our specialized services enable targeted research and sophisticated biomedical applications.
BOC Sciences provides antibody–drug conjugation (ADC) , peptide/protein–fluorophore conjugation, oligonucleotide conjugation, and nanoparticle functionalization. Our bioconjugation workflows are optimized for stability, reproducibility, and site-specificity, enabling advanced drug delivery and diagnostics.
We specialize in custom labeling of biomolecules with fluorescent dyes, stable isotopes, biotin, and enzymes. Our labeling services support cellular imaging, mechanism-of-action studies, target engagement, and molecular tracking applications across research pipelines.
Our synthetic chemistry covers a wide range of reaction types including oxidation, reduction, halogenation, olefination, C–H activation, azidation, cyanation, diazotization, and coupling reactions. With route flexibility and methodological diversity, we solve complex synthetic challenges efficiently.
BOC Sciences supports route scouting, reaction condition optimization, scale-up synthesis , and tech transfer. Our process R&D team delivers cost-effective and scalable chemistry solutions with high reproducibility, supporting preclinical and pilot production phases.
BOC Sciences has built a highly specialized medicinal chemistry platform that integrates synthetic chemistry, analytical science, and process development. Our platform supports comprehensive services from early-stage molecule design to scalable synthesis and late-phase optimization. With extensive technical depth and a robust infrastructure, we ensure speed, quality, and compliance across every step of medicinal chemistry-driven drug development.
| Capability Module | Representative Techniques |
| Multi-Step Organic Synthesis | Broad reaction coverage (e.g., coupling, condensation, cyclization); efficient route design and scale-up |
| Complex Molecule Construction | Synthesis of heterocycles, bridged/macrocyclic compounds with stereochemical complexity |
| Purification Technologies | Column chromatography, preparative HPLC, recrystallization for high-purity compound isolation |
| Structural Characterization | NMR (1H, 13C), LC-MS, HRMS, IR, and UV-Vis for structure confirmation and purity analysis |
| Asymmetric Synthesis & Chiral Resolution | Enantioselective catalysis, chiral chromatography, and stereochemical verification methods |
| Special Reaction Conditions | Low-temperature synthesis (–78℃), high-pressure hydrogenation, anhydrous/inert atmosphere handling |
| Bioconjugation & Labeling | Site-specific conjugation, linker design, fluorescent and isotope labeling (e.g., FITC, 13C, biotin) |
| Process Optimization & Scale-Up | DoE-based optimization, impurity profiling, kilogram-scale synthesis, green chemistry practices |
BOC Sciences' medicinal chemistry service platform is equipped with a comprehensive suite of advanced instrumentation to support every stage of small molecule drug discovery and development. Our platform enables efficient compound synthesis, purification, structural elucidation, and analytical characterization, ensuring data integrity and reproducibility throughout the medicinal chemistry workflow.
At BOC Sciences, our integrated medicinal chemistry capabilities support the discovery, optimization, and development of diverse therapeutic modalities. From small molecules to complex bioconjugates and nucleic acid-based drugs, our platform enables precise synthesis, modification, and analytical characterization across various drug classes. Below are the key types of drugs supported:
We support the development of classical and targeted small molecules, including antipyretics, antibiotics (e.g., penicillins), kinase inhibitors, epigenetic modulators, CNS drugs, and metabolic agents.
Our expertise enables an efficient synthesis of ADCs, peptide-drug conjugates, and antibody-oligonucleotide conjugates using cleavable/non-cleavable linkers and site-specific conjugation.
We facilitate the design and synthesis of ASOs, siRNAs, and mRNA-based therapies, supporting sequence modification, delivery system integration (e.g., lipid nanoparticles), and impurity profiling.
BOC Sciences provides synthetic and analytical support for peptide drugs (e.g., semaglutide) and engineered proteins, including monoclonal antibodies and fusion proteins.
Our chemical expertise supports CAR-T constructs, gene modulation systems (e.g., guide RNA synthesis), and oncolytic viruses by providing synthetic linkers, delivery vectors, and stability enhancers.
We offer semi-synthesis and derivatization of natural products and provide analytical services for complex TCM formulations to support active ingredient identification and quality control.
We synthesize and label molecular imaging agents and fluorescent probes for diagnostic and theranostic applications, ensuring high purity and stability under physiological conditions.
We support the development of PROTACs, molecular glues, and allosteric inhibitors through advanced bifunctional molecule design, linker chemistry, and structure-activity optimization.
Engage closely with clients to understand their specific goals in drug discovery, including therapeutic targets, chemical space of interest, lead identification challenges, and project timelines. This foundational step ensures that our synthetic and optimization strategies are precisely aligned with the client's technical and strategic needs.
Develop preliminary synthetic routes based on literature precedents and retrosynthetic analysis. Evaluate key parameters such as synthetic accessibility, scalability, safety, and cost. Computational tools and expert consultation are used to anticipate potential bottlenecks and select the most viable pathways.
Conduct rapid and flexible synthesis of target molecules including small molecules, lipids, peptides, nucleotides, and intermediates. Our experienced chemists utilize diverse reaction types and building blocks to deliver high-purity compounds. Parallel synthesis and SAR-driven analog libraries can be generated upon request.
Utilize advanced purification techniques (e.g., flash chromatography) and analytical instrumentation (e.g., NMR, LC-MS) to ensure compound identity, purity, and structural integrity. Analytical data packages are prepared for each compound to support downstream research and development activities.
Iteratively modify chemical structures based on SAR insights to enhance potency, selectivity, solubility, and metabolic stability. Integrate medicinal chemistry with ADME and toxicity data to systematically advance hits to lead and lead to candidate stages, minimizing development risk.
Deliver final compounds along with comprehensive documentation including synthetic route, analytical data, yield, storage conditions, and usage guidelines. Upon request, additional support such as method transfer, scale-up strategy, or impurity profile reports can be provided to facilitate project continuity.
Medicinal Chemistry services encompass multi-step organic synthesis, complex molecule construction, chiral synthesis, purification and separation techniques, structural characterization, specialized reaction condition handling, and process optimization. Additional expertise includes bioconjugation, labeling methods, and handling of unstable compounds to support the full drug discovery pipeline.
A professional Medicinal Chemistry platform combines deep synthetic expertise with advanced analytical capabilities to efficiently design, synthesize, and characterize complex molecules. This accelerates discovery timelines, enhances compound quality and reproducibility, and ensures robust support for early-stage drug research.
BOC Sciences provides comprehensive medicinal chemistry support, from custom synthesis and chiral synthesis to bioconjugation and process R&D . Equipped with advanced instrumentation and a wide range of synthetic technologies, we emphasize process optimization, quality control, and scalable manufacturing to help clients accelerate and de-risk their drug discovery programs.
