In chemistry, building blocks are molecules or ions that can be combined to create more complex structures. They are typically small, simple molecules that can be easily manipulated and modified to achieve a desired outcome. BOC Sciences with seasoned chemists would provide a comprehensive supply of building blocks synthesis service.
During the last decades, the synthesis of building blocks has been explored by numerous groups, which are used in pharmaceutical products and other biologically active substances. Building blocks are important intermediates for many drugs and have major significance in the discovery and synthesis of drugs. Many important substances and some significant effects of natural drugs and synthetic drugs, such as chlorophyll, heme, and nucleic acid, contain heterocyclic structure.
The heterocyclic compounds or heterocyclic compounds containing nitrogen atoms or fluorine atoms can be introduced into building blocks. Further building blocks as intermediates can be used to synthesize the subsequent drugs or compounds, which can improve or change the properties of the drugs or compounds. In addition, the introduction of sulfur and nitrogen-containing sulfonamide on the molecules of isopimaric acid can wide the range of effective anti-cancer activity of isopimaric acid. In a word, some necessary groups can be introduced into building blocks and change the properties of subsequent compounds.
In addition to biological building blocks, BOC Sciences provides a broad portfolio of chemical building blocks essential for organic synthesis, materials science, and pharmaceutical development. Our offerings include functionalized small molecules such as halides, aldehydes, ketones, carboxylic acids, amines, and esters, which serve as versatile intermediates in various chemical transformations. We also supply aromatic and heterocyclic compounds that offer stable and diverse scaffolds crucial for drug discovery and polymer design. Key modules for cross-coupling reactions, including boronate esters and organostannanes, are available to enhance synthetic efficiency and molecular complexity. Furthermore, we provide chiral building blocks catering to enantioselective synthesis requirements, as well as polymer precursors for advanced material applications. This comprehensive range ensures that our clients can access high-quality, reliable chemical building blocks tailored to their specific research and development needs.
Table.1 BOC Sciences Chemical Building Blocks Product Portfolio.
| Chemical Building Block Category | Example Products / Subtypes |
| Functionalized Small Molecules | Alkyl Halides, Aldehydes, Ketones |
| Carboxylic Acids, Amines, Esters | |
| Aromatic and Heterocyclic Compounds | Substituted Benzenes, Pyridines, Indoles |
| Other N-heterocycles | |
| Cross-Coupling Modules | Boronate Esters, Organostannanes, Aryl Halides |
| Chiral Building Blocks | Enantiomerically Pure Intermediates |
| Chiral Auxiliaries | |
| Polymer Precursors | Monomers for Functional Polymers |
| Prepolymers for Specialty Materials |
If you are interested in our chemical building blocks, please contact us directly for pricing and availability. Our technical sales team offers tailored synthesis solutions to meet your specific project requirements. Submit your inquiry via our online form or email us with details of your needs, and we will respond promptly to support your development process.
The building blocks, or monomers, come in various forms, each with its unique chemical makeup and properties, and are capable of forming complex molecular structures through covalent bonding mechanisms.
One such set of building blocks is amino acids, the elemental constituents of proteins. These small molecules harbor both amino and carboxyl functional groups, allowing them to partake in peptide bond formation, ultimately leading to the synthesis of proteins.
Nucleotides are the molecular building blocks of nucleic acids, which form the genetic code of all living organisms. Comprising a nitrogenous base, a sugar molecule, and a phosphate group, nucleotides play a vital role in the storage and transmission of genetic information. The four nucleotides that comprise DNA are adenine, thymine, guanine, and cytosine, each with distinct hydrogen bonding patterns, enabling the unique sequence of DNA, critical to an organism's genetic blueprint.
Another critical class of building blocks is monosaccharides, the fundamental unit of carbohydrates. These simple sugars can be linked together through glycosidic bonds to form more complex carbohydrates, such as disaccharides and polysaccharides.
Finally, aromatic compounds, with their distinct cyclic structures, serve as crucial building blocks for a wide range of organic compounds, including pharmaceuticals and polymers. Aromatic compounds contain alternating double bonds in their cyclic structure, which imparts unique electronic properties, making them highly versatile and essential in synthetic chemistry.
Table.2 BOC Sciences Biological Building Blocks Product Portfolio.
| Building Block Category | Example Products / Subtypes |
| Amino Acids | D-Amino Acids |
| Protected Amino Acids | |
| Chiral Purified Amino Acids | |
| Nucleotides and Nucleosides | Modified Nucleotides |
| Labeled Nucleotides | |
| Stabilized Nucleotides | |
| Monosaccharides and Oligosaccharides | Amino Sugars |
| Polysaccharide Fragments | |
| Fatty Acids and Glycerol Derivatives | Modified Fatty Acids |
| Triglycerides and Phospholipids | |
| Oligonucleotides | Modified Oligonucleotides |
| Fluorescently Labeled Oligonucleotides | |
| Peptide Nucleic Acids (PNA) | |
| Small Molecule Metabolites and Cofactors | Coenzyme A |
| Protein Modification Reagents and Linkers | Protein Crosslinkers |
| Fluorescent Labeling Reagents | |
| Affinity Tag Linkers |
For pricing and custom synthesis inquiries, please contact us directly. Our technical sales team will respond promptly to support your project needs.
Drug designThe process of designing and synthesizing new drugs is a complex endeavor, requiring meticulous planning and a deep understanding of the molecular underpinnings of disease. The first step in this process is the identification of a drug target, a specific molecule or protein involved in a disease process. Once a drug target has been identified, a veritable arsenal of chemical building blocks is employed to design and synthesize molecules capable of interacting with the target and modulating its activity.
Prodrug developmentIn the drug development, prodrugs represent a particularly intriguing strategy for enhancing drug efficacy. These biologically inactive compounds are metabolized in vivo to produce an active drug, thereby improving the pharmacokinetic properties of the drug. Building blocks are employed in the creation of prodrugs by attaching a biologically inactive moiety to an active drug, thereby enabling the drug to be delivered more effectively to its target site.
Target discoveryThe discovery of new drug targets is an integral part of the drug development process, relying heavily on the creation of large libraries of compounds to be screened for activity against a specific target. High-throughput screening (HTS) is a powerful method used to screen large numbers of compounds for activity against a specific drug target. Building blocks play a pivotal role in the creation of these libraries, providing a vast array of molecular structures to be screened using HTS.
Biocatalysis, which is applying enzymes for organic synthetic transformations, has become a commonly applied green technology for selected asymmetric transformations. Because the biodegradability of the catalyst and the benign reaction conditions eliminate toxic reagents and solvents, it can reduce the manufacturing costs and the environmental impact. Biocatalytic preparations are important methods for synthesis of building blocks with high optical purity. Biocatalysis can be used in the synthesis of enantiopure building blocks for pharmaceuticals.
Using some familiar compounds to introduce the structure that you want into building blocks is a simple, and easily controlled method. Fluorine-containing building blocks, heterocyclic-containing building blocks, aromatic-containing building blocks, and nitrogen-containing building blocks can be synthesized by chemical routine. For example, with simple and efficient chemical routine, simple fluorine-containing building blocks are synthesized, and subsequently, different fluorine heterocyclic compounds can be synthesized. Finally, they can be applied to synthesize fluorinated drugs or convert to other fluorinated heterocyclic compounds.
BOC Sciences employs the latest technology and instrumentation to enable high-throughput, scalable, and quality-driven building block synthesis. Automated and parallel reactors are available for seamless workflows, as well as analytical instruments including NMR, LC-MS, and IR spectroscopy to enable structural accuracy, purity control, and fast turnarounds from milligram to kilogram scales. Please see our main equipment below:
Customers submit their requests via our online form or email, including target structure, functional groups, required purity, quantity, and other specifications. Our technical sales team responds promptly with initial consultation.
Our chemists conduct a feasibility assessment of the synthetic route, considering raw material availability, reaction complexity, and timeline. A detailed quotation and project scope are provided for client confirmation.
Based on the approved plan, synthetic chemists design the reaction pathway and prepare the necessary reagents and starting materials to ensure a timely project launch.
The synthesis is carried out according to established protocols, with in-process QC checkpoints (e.g., NMR, LC-MS) to monitor reaction progress and intermediate purity.
Purification is conducted via techniques such as column chromatography, crystallization, or HPLC. Structural confirmation and purity assessment are performed using NMR, LC-MS, GC-MS, HRMS, or X-ray analysis.
Upon completion, products are packaged according to customer requirements and shipped with a certificate of analysis (COA), analytical data, and technical documents. Secure and timely delivery is arranged through our logistics network.
BOC Sciences can provide various types of methods to help you synthesize building block, whatever group or chemical constitutions you want to introduce. We are experts at designing the routine and using multiple techniques (NMR, LC-MS, GC-MS, and X-ray) to analyze compounds after the building block synthesis completed. The time of building block synthesis is very fast with your demand. Our experienced chemists offer responsive technical support, flexible scale-up options, and full documentation to ensure seamless integration into your research workflows, accelerating your project timelines efficiently.
In biosynthesis, building blocks refer to the fundamental molecular components used to assemble biological macromolecules. These include amino acids (the building blocks of proteins), nucleotides (the building blocks of DNA and RNA), monosaccharides (used to form polysaccharides such as cellulose and glycogen), and fatty acids with glycerol (which contribute to lipid construction). Through a series of enzyme-catalyzed reactions, these small molecules are efficiently integrated within cells to generate complex biopolymers with defined biological structures and functions.
In organic synthesis, building blocks typically refer to key intermediates or molecular fragments with defined functional groups that enable stepwise construction of target compounds. Common building blocks include halides, aldehydes, ketones, carboxylic acids, amines, and esters, as well as aromatic and heterocyclic scaffolds. These components participate in a range of transformations such as cross-coupling, condensation, and nucleophilic substitution. In modern synthetic strategies, the careful selection of building blocks plays a critical role in optimizing synthetic routes, enhancing molecular diversity, and improving overall efficiency.
BOC Sciences provides a broad range of chemical and biological building blocks to support drug discovery and related research. Our chemical building blocks include boronic acids, heterocycles, halides, carboxylic acids, amines, aldehydes, ketones, and chiral scaffolds, as well as fragment libraries and custom intermediates. On the biological side, we offer amino acids, nucleotides, monosaccharides, fatty acids, and other biomolecule derivatives for peptide synthesis, oligonucleotide assembly, and glycobiology applications. With scalable production and reliable supply, BOC Sciences delivers quality building blocks to accelerate your research and development projects.
All building blocks supplied by BOC Sciences undergo stringent quality control, including NMR, MS, HPLC, and COA documentation. Our QA/QC processes are designed to ensure consistent batch-to-batch quality, reproducibility, and reliable performance in diverse synthetic applications.
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